De Meirleir:


Signifikant meer gram-positieve bakteria in ontlasting.






Prof. de Meirleir en kollega's hebben de stoelgang van ME(CVS)-patiŽnten onderzocht.


Hun konklusie luidt:

In de ontlasting van ME(CVS)-patiŽnten komen beduidend meer

gram-positieve anaerobe, D-melkzuur producerende bakteria voor.


De symptomen van D-melkzuur vergiftiging lijken deels op die van ME(CVS): klik hier.


Deze bevinding sluit aan bij de excessieve H2S-produktie in de darmen (klik hier).


Die theorie van prof. de Meirleir over overbegroeiing van de darmen en de H2S-theorie

is terug te vinden in het verslag van de Invest in ME-konferentie: klik hier.




Increased D-Lactic Acid Intestinal Bacteria in Patients with Chronic Fatigue Syndrome

In Vivo July 2009 23:621-628.

Sheedy JR, Wettenhall RE, Scanlon D, Gooley PR, Lewis DP, McGregor N, Stapleton DI, Butt HL, De Meirleir KL.



Patients with chronic fatigue syndrome (CFS)

are affected by

symptoms of

cognitive dysfunction and

neurological impairment,

the cause of which has yet to be elucidated.



these symptoms

are strikingly similar to

those of patients

presented with D-lactic acidosis.


A significant increase of

Gram positive facultative anaerobic faecal microorganisms

in 108 CFS patients

as compared to 177 control subjects (p<0.01)

is presented in this report.


The viable count of

D-lactic acid producing

Enterococcus and

Streptococcus spp.

in the faecal samples

from the CFS group

(3.5◊107 cfu/L and 9.8◊107 cfu/L respectively)

were significantly higher than

those for the control group

(5.0◊106 cfu/L and 8.9◊104 cfu/L respectively).


Analysis of exometabolic profiles of

Enterococcus faecalis and

Streptococcus sanguinis,

representatives of

Enterococcus and

Streptococcus spp. respectively,

by NMR and HPLC

showed that

these organisms

produced significantly more

lactic acid (p<0.01)

from 13C-labeled glucose,

than the Gram negative Escherichia coli.




E. faecalis and

S. sanguinis

secrete more D-lactic acid

than E. coli.


This study suggests

a probable link

between intestinal colonization of

Gram positive facultative anaerobic D-lactic acid bacteria and

symptom expressions

in a subgroup of patients with CFS.


Given the fact that

this might explain

not only neurocognitive dysfunction in CFS patients

but also mitochondrial dysfunction,

these findings may have important clinical implications.




Met dank aan Jan van Roijen (Help ME Circle) en Rubia.