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Geen XMRV/MLV gevonden

in patiŽnten die in Mikovits-studie

als XMRV-geinfekteerd aangemerkt werden.






In de kontext van hetgeen in de vorige rubriek gemeld werd,

verscheen vandaag wederom een negatieve XMRV-studie, ditmaal in Science.


Veel patiŽnten, allen afkomstig uit de kliniek van Dan Peterson, die gebrouilleerd is met

het Whittemore-Peterson Instituut, waren in de Science-studie uit 2009 positief bevonden!




No evidence of murine-like gammaretroviruses

in CFS patients previously identified as XMRV-infected.

Science. Published Online 31 May 2011. doi: 10.1126/science.1204963


Konstance Knox, Donald Carrigan, Graham Simmons, Fernando Teque, Yanchen Zhou, John Hackett Jr., Xiaoxing Qiu, Ka-Cheung Luk, Gerald Schochetman, Allyn Knox, Andreas M. Kogelnik, Jay A. Levy.






Murine-like gammaretroviruses (MLVs),

most notably XMRV [xenotropic murine leukemia virus (X-MLV)Ėrelated virus],

have been reported to be present in

the blood of patients with chronic fatigue syndrome (CFS).


We evaluated

blood samples from 61 patients with CFS from a single clinical practice,

43 of whom had previously been identified as XMRV-positive.


Our analysis included

polymerase chain reaction and

reverse transcription polymerase chain reaction procedures

for detection of viral nucleic acids and

assays for detection of infectious virus and virus-specific antibodies.


We found no evidence of XMRV or other MLVs in these blood samples.


In addition,

we found that

these gammaretroviruses were strongly (X-MLV) or partially (XMRV) susceptible to

inactivation by sera from CFS patients and healthy controls,

which suggested that

establishment of a successful MLV infection in humans would be unlikely.


Consistent with previous reports,

we detected MLV sequences in commercial laboratory reagents.


Our results indicate that previous evidence

linking XMRV and MLVs to CFS

is likely attributable to laboratory contamination.


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