van Weyenbergh:

over overeenkomsten en verschillen met HLTV-1 en HIV,

overdraagbaarheid en uitbraken ME/CVS etc.








A third pathogenic and lymphotropic human retrovirus

AIDS Rev. 2010; 12: 121-122.

Johan van Weyenbergh.





Chronic fatigue syndrome

is characterized by

persistent or relapsing debilitating fatigue,

musculoskeletal pain, and

neurocognitive difficulties,

as well as immunological abnormalities

(Reeves, et al. BMC Med. 2005;3:19; Devanur, et al. Clin Virol. 2006;37:139-50).




If the retroviral link revealed by Lombardi, et al. turns out to be "druggable",

CFS will automatically upgrade

from a neglected disease to a "hot target" for the pharmaceutical industry.





the sequence data presented by Lombardi, et al., albeit limited,

seems to suggest that XMRV, much like HTLV 1

(Van Dooren, et al. Mol Biol Evol. 2004;21:603 11),

may be a slowly evolving retrovirus,

indicating viral propagation might occur mainly through host cell replication

rather than through HIV-like, reverse transcriptase-mediated, cell-to-cell spread.





previously described outbreaks of "epidemic" CFS,

e.g. in a symphonic orchestra, a school, and a convent,

challenge an HIV like epidemiological spread.





CD4 or CD8 T -cell subsets are not quantitatively different in CFS patients

(Tirelli, et al. Scand J Immunol. 1994;40:601-8),

but altered NK cell levels and function have been repeatedly reported.



considering the pathogenic profile, molecular evolution, and broad cellular tropism,

including pan-lymphotropism,

XMRV seems to display HTLV-1-like characteristics.





much unlike HIV-1/AIDS and HTLV-1-associated illnesses,

adult T -cell leukemia/lymphoma (ATLL) and

HTLV 1-associated myelopathy/tropic spastic paraparesis (HAM[TSP),

where disease onset takes years or decades, respectively,

CFS is generally characterized by a sudden onset,

most often accompanied by flu-like syndromes.




Met dank aan Rob, die me attendeerde op bovenstaand artikel.