Follow FrankTwisk on Twitter  





Oude spieren

in jonge lichamen:

overzichtsartikel van

afwijkingen die

spierproblemen verklaren








In een overzichtsartikel, geschreven door Tiziana Pietrangelo, Stefania Fulle, en collega's,

worden een aantal afwijkingen die zijn geobserveerd in ME/CVS-patiŽnten samengevat.


De afwijkingen verklaren het verschijnsel van 'oude spieren (sarcopenia) in jonge lichamen':




Waarom de auteurs uiteindelijk met de aanbeveling komen om de spieren te trainen, is mij een raadsel...






Old muscle in young body: an aphorism describing the chronic fatigue syndrome.

Eur J Transl Myol. 2018 Sep 7;28(3):7688. doi: 10.4081/ejtm.2018.7688. eCollection 2018 Jul 10.

Pietrangelo T, Fulle S, Coscia F, Gigliotti PV, FanÚ-Illic G.




The chronic fatigue syndrome (CFS)

otherwise known as myalgic encephalomyelitis (ME),

is a debilitating syndrome whose identification is very complex

due to lack of precise diagnostic criteria.


This pathology begins with

limitations in duration and intensity of exercise and

rapid onset of pain during physical activity.


Its etiology is unknown, and symptoms are not limited to the muscles.


Epidemiology is rather difficult to delimit,

even if it affects mainly young (20-40 years), female subjects.


The results of muscular research show some peculiarities

that can justify what has been observed in vivo.


In particular,

  1. presence of oxidative damage of
  2. lipid component of biological membranes and DNA

    not compensated by the increase of the scavenger activity;

  3. Excitation-Contraction (E-C) alteration with modification of Ca2+ transport;
  4. passage from slow to fast fiber phenotype;
  5. inability to increase glucose uptake;
  6. presence of mitochondrial dysfunction; and
  7. genes expressed differentially
  8. (particularly those involved in energy production).

The skeletal muscles of CFS / ME patients show

a significant alteration of the oxidative balance

due to mitochondrial alteration and of the fiber phenotype composition

as shown in sarcopenic muscles of the elderly.


Vice versa, the muscle catabolism

does not appear to be involved in the onset of this syndrome.


The data support the hypothesis that

patients with CFS are subjected to some of the problems typical for muscle aging,

which is probably related to

disorders of muscle protein synthesis and biogenesis of mitochondria.


Patients with CFS can benefit from an appropriate training program

because no evidence suggests that physical exercise worsens symptoms.


Type, intensity and duration of any physical activity

that activates muscle contraction (including Electrical Stimulation) require further investigation

even if it is known that

non-exhaustive physical activity decreases painful symptomatology.






Chronic Fatigue Syndrome; Myalgic Encephalomyelitis; Systemic Exertion Intolerance Disease;

painful symptomatology; physical exercise; skeletal muscle



PMID: 30344981


PMCID: PMC6176399


DOI: 10.4081/ejtm.2018.7688