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Le Bon:


minder krachtig

tijdens diepe slaap










Volgens een studie van Le Bon en collega's zijn de deltagolven minder intensief in ME/CVS.

Deltagolven zijn kenmerkend voor fase 3 en 4 van de niet-REM-slaap (de diepe slaap).


Minder diepe slaap in ME/CVS werd in 2007 door van Hoof en anderen gerapporteerd.





Ultra-slow delta power in chronic fatigue syndrome.

Psychiatry Res. 2012 Jul 6. doi: 10.1016/j.psychres.2012.06.027

Le Bon O, Neu D, Berquin Y, Lanquart JP, Hoffmann R, Mairesse O, Armitage R.



Received 19 November 2011.

Revised 3 May 2012.

Accepted 20 June 2012.

Available online 6 July 2012.






The role of sleep in patients diagnosed with chronic fatigue syndrome is not fully understood.


Studies of polysomnographic and quantitative sleep electroencephalographic (EEG) measures

have provided contradictory results,

with few consistent findings in patients with Chronic Fatigue Syndrome (CFS).


For the most part, it appears that

delta EEG activity may provide the best discrimination between patients and healthy controls.


A closer examination of delta activity

in the very slow end of the frequency band

is still to be considered in assessing sleep in CFS.


The present preliminary study compared

absolute and relative spectral power

in conventional EEG bands and ultra-slow delta (0.5-0.8Hz)

between 10 young female patients with the CFS and

healthy controls without psychopathology.


In absolute measures,

the ultra-slow delta power was lower in CFS,

about one-fifth that of the control group.


Other frequency bands did not differ between groups.


Relative ultra-slow delta power was lower in patients than in controls.


CFS is associated with lower ultra-slow (0.5-0.8Hz) delta power,

underscoring the importance of looking beyond conventional EEG frequency bands.


From a neurophysiological standpoint,

lower ultra-slow wave power may indicate

abnormalities in the oscillations in membrane potential or

a failure in neural recruitment in those with CFS.




PMID: 22771174




AlphaĖdelta; Sleep; SWA; Sleepiness