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Rovigatti: Is het MFV-virus de oorzaak van ME/CVS en kanker-gerelateerde vermoeidheid?






Obscure theorie of een interessante hypothese?


Volgens dr. Ravigotti, kankeronderzoeker, is het Micro-Foci inducing Virus (MFV), een onbekend virus, mogelijk de oorzaak van ME/CVS en kanker-gerelateerde "vermoeidheid".


De vier argumenten die hij hiervoor aandraagt:

  1. de aangetoonde aanwezigheid van MFV in epidemische clusters,
  2. de associatie van MFV met de interferon-gerelateerde afweersysteem,
  3. de relatie van MFV met het RNAse-L-afweersysteem,
  4. de hersensafwijkingen die mogelijkerwijs m.b.v. MFV verklaard kunnen worden.

Dr. Ravigotti stelt terecht dat elke kandidaat-pathogeen epidemieŽn moet kunnen verklaren.





Chronic fatigue syndrome (CFS) and cancer related fatigue (CRF):

two "fatigue" syndromes with overlapping symptoms and possibly related aetiologies.

Neuromuscular Disorders. December 2012 Dec 1;22(3): S235-S241.


Rovigatti U.


Department of Oncology,

Transplantation and New Biomedical Technologies,

University of Pisa Medical School,







In July 2010, at the Muscle Fatigue Meeting,

I presented an overview of Chronic Fatigue Syndrome and Cancer Related Fatigue,

emphasizing a critical interpretation of the potential association

between Chronic Fatigue Syndrome and Cancer Related Fatigue and

a newly discovered retrovirus: Xenotropic Murine Related Virus.


Since this association was hotly debated at that time,

I suggested at the Meeting that it was wrong and

most likely due to the identification of the wrong virus culprit.


Today, 20 months after the Meeting,

the first part of our prediction has turned out to be correct,

as Xenotropic Murine Related Virus was shown to be a laboratory-created artefact.



the potential association of fatigue-syndromes with an infection (most likely viral)

is sustained by a plethora of evidence and

this overview will initially summarize data suggesting prior viral infection(s).


The principal hypothesized mechanisms

for both peripheral and central Chronic Fatigue Syndrome/Cancer Related Fatigue

will be then summarized,

also indicating plausible associations and triggering factors.


All evidence accrued so far suggests that

further research work should be performed in this interesting area and

in order to identify an infectious agent for

Chronic Fatigue Syndrome/Cancer Related Fatigue.


One candidate RNA virus, Micro-Foci inducing Virus,

will be described in this overview.





Chronic Fatigue Syndrome, Cancer Related Fatigue, Xenotropic Murine Related Virus




Met dank aan Rob en dr. Rovigatti (voor het ter beschikking stellen van het manuscript).