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genetisch materiaal (RNA)

van het Borna-virus

aanwezig in

1 op de 8 CVS-patiŽnten.






In een recente studie hebben Zhang en collega's vonden m.b.v. de PCR-techniek

genetisch materiaal (RNA) van het Borna-virus bij 12,7% van de CVS-patiŽnten.


Het Borna-virus werd eerder in verband gebracht met CVS (klik hier, hier, hier en hier), maar

Lipkin en collega's konden volgens een studie uit 1999 geen RNA van het Borna-virus vinden.


Het Borna-virus is een neurotropisch virus dat zich volgens Horie genesteld heeft in het DNA van de gastheer. Volgens anderen zijn ook nieuwe infecties (van buitenaf) ziekmakend, bijv. in woelmuizen.








Evidence for Borna disease virus infection in

neuropsychiatric patients in three western China provinces.

Eur J Clin Microbiol Infect Dis. 2013 Oct 30. doi: 10.1007/s10096-013-1996-4.

Zhang L, Xu MM, Zeng L, Liu S, Liu X, Wang X, Li D, Huang RZ,

Zhao LB, Zhan QL, Zhu D, Zhang YY, Xu P, Xie P.





Borna disease virus (BDV) is a non-cytolytic, neurotropic RNA virus

that can infect a wide variety of vertebrate species from birds and primates to humans.


Several studies have been carried out

to investigate whether BDV is associated with neuropsychiatric diseases.


However, this association is still inconclusive.


Two panels of subjects consisting of 1,679 various neuropsychiatric patients and

healthy people from three western China provinces were enrolled in this study.


BDV p24 or p40 RNA in peripheral blood mononuclear cells (PBMCs) were detected

in the first panel of 1,481 subjects

using reverse transcription quantitative polymerase chain reaction (RT-qPCR) and

cerebrospinal fluid (CSF) samples from the BDV RNA-positive individuals

were subjected to BDV p24 antibodies testing by enzyme-linked immunosorbent assay (ELISA).


BDV p24 or p40 RNA in PBMCs and p24 antibodies in plasma

were detected in the second panel of 198 subjects by RT-qPCR and Western blot.


A higher prevalence for BDV RNA was demonstrated in patients with

viral encephalitis (6.70 %), Guillain-Barrť syndrome (6.70 %),

schizophrenia (9.90 %) and chronic fatigue syndrome (CFS) (12.70 %)

compared to healthy controls in the first panel.


CSF p24 antibodies were demonstrated in three viral encephalitis patients,

two schizophrenia patients and two major depressive disorder (MDD) patients.


The prevalences of p24 antibodies in plasma from patients with

viral encephalitis (13.24 %), multiple sclerosis (25.00 %) and Parkinson's disease (22.73 %)

were significantly higher than healthy controls.


This study demonstrates that

BDV infection also exists in humans from three western China provinces, and

suggests the involvement of the contribution of BDV in the aetiology of Chinese patients

with some neuropsychiatric disorders,

including viral encephalitis, schizophrenia, CFS, multiple sclerosis and Parkinson's disease.



PMID: 24170181




Met dank aan Manja.