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oxidatieve (en nitrosatieve) stress

is gerelateerd aan

HPA-as afwijkingen








Volgens een recente studie van Kubow, Sorenson en Jason zijn

de verhoogde concentraties F2- en F3-isoprostanenen isofuranen,

markers voor oxidatieve en nitrosatieve stress,

gecorreleerd aan endocriene afwijkingen (DHEA:cortisol ratio),

in ieder geval in "senioren" met ME/CVS (65 jaar en ouder).


Opmerking FT:

Er zijn diverse plausibele redenen voor HPA-as disfunctie (o.m. bijnier-insufficiëntie) in ME/CVS,

zoals inflammatie, IL-10-productie, en oxidatieve en nitrosatieve stress (artikel in bewerking).





Novel associations of F2-isoprostanes, F3-isoprostanes and isofurans

in older adults with chronic fatigue syndrome: an exploratory study.

Kubow S, Sorenson M, Alkazemi D, Roberts J L II, Adamski KN, Jason LA.

Clin Res. 2015 Jul 15;1(1): doi: 10.16966/clroa.103.





Plasma levels of F2-isoprostanes (F2-IsoPs),

a whole body oxidative stress marker,

have been noted to be elevated in populations with chronic fatigue syndrome (CFS).


We hypothesized that the oxidative stress biomarkers of

F2-isoprostanes (F2-IsoPs), isofurans (IsoFs) and F3-isoprostanes (F3-IsoPs)

are related to hypothalamic-pituitary-adrenal (HPA) axis dysregulation

in chronic fatigue syndrome (CFS) subjects

assessed by plasma dehydroepiandrosterone (DHEA) and cortisol and

gene expression of sirtulin-1 [sirtuin-1, FT] (SIRT1).


Plasma samples were obtained from nine CFS individuals aged 65 years or older.


The mean levels of plasma F2-IsoPs (M=178 pg/ml, SD=100) and IsoFs (M=266 pg/ml, SD=205)

were several-fold higher than previously reported in healthy subjects.


F2-IsoPs:F3-IsoPs and SIRT1 were negatively associated (r=– .674, p<.05)

whereas F3-IsoPs were inversely correlated with DHEA (r=– .586, p<.05) and

positively associated with SIRT1 (r=.733, p<.05).


After correction for age and sex,

the F2-IsoPs:IsoFs ratio was positively correlated to DHEA:cortisol (r=.758, p<.05).


The findings indicate

that plasma IsoFs and F2-IsoPs are elevated in older subjects with CFS and

that isoprostane and isofuran ratios are associated with HPA dysregulation.





Chronic fatigue syndrome; isoprostanes; isofurans; cortisol;

hypothalamic-pituitary-adrenal axis; mass spectrometry