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Risicofactoren voor

cardiovasculaire problemen

bij ME/CVS-patiŽnten






In een overzichtsartikel verschaffen dr. Maes en ondergetekende

een overzicht van de biologische afwijkingen

die een risicofactor voor cardiovasculaire complicaties vormen:

  • chronische laaggradige inflammatie (immuunactivatie etc.),
  • oxidatieve en nitrosatieve stress (superoxide, stikstofoxide, peroxynitriet),
  • uitputting van anti-oxidanten (als gevolgen van oxidatieve/nitrosatieve stress),
  • een lekke darm waardoor enterobacteriŽn in de bloedstroom terecht kunnen komen,
  • afname van omega-3- en een toename van omega-6-vetzuren en
  • fysiologische stress (o.a. bacteriŽle/virale infecties) en psychologische stress.


Voor de volledige tekst van onderstaande studie, klik op onderstaand logo:







Chronic fatigue syndrome increases heart disease risk


News - Chronic Fatigue Syndrome News

Written by Matthew Hogg

Saturday, 09 January 2010

A new study sheds light on the underlying mechanisms explaining the increased risk of early death

due to heart failure in chronic fatigue syndrome patients seen in earlier research.






Why myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may kill you:

disorders in the inflammatory and oxidative and nitrosative stress (IO&NS) pathways

may explain cardiovascular disorders in ME/CFS.

Neuro Endocrinol Lett. 2009 Dec 29;30(6). [Epub ahead of print]

Maes M, Twisk FNM.



There is evidence that

disorders in inflammatory and oxidative and nitrosative (IO&NS) pathways and

a lowered antioxidant status

are important pathophysiological mechanisms

underpinning myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).


Important precipitating and perpetuating factors for ME/CFS are (amongst others)

bacterial and viral infections;

bacterial translocation due to an increased gut permeability; and

psychological stress.


Recently, Jason et al (2006)

reported that the mean age of

patients with myalgic encephalomyelitis/chronic fatigue syndrome

dying from heart failure, i.e. 58.7 years,

is significantly lower than the age of those dying from heart failure

in the general US population, i.e. 83.1 years.


These findings implicate that

ME/CFS is a risk factor to cardio-vascular disorder.


This review demonstrates that

disorders in various IO&NS pathways

provide explanations for the earlier mortality

due to cardiovascular disorders in ME/CFS.


These pathways are:

  1. chronic low grade inflammation
  2. with extended production of nuclear factor kappa B and COX-2 and

    increased levels of tumour necrosis factor alpha;

  3. increased O&NS
  4. with increased peroxide levels, and phospholipid oxidation

    including oxidative damage to phosphatidylinositol;

  5. decreased levels of specific antioxidants,
  6. i.e. coenzyme Q10, zinc and dehydroepiandrosterone-sulphate;

  7. bacterial translocation as a result of leaky gut;
  8. decreased omega-3 polyunsatutared fatty acids (PUFAs), and
  9. increased omega-6 PUFA and saturated fatty acid levels; and

  10. the presence of viral and bacterial infections and psychological stressors.

The mechanisms whereby each of these factors

may contribute towards cardio-vascular disorder

in ME/CFS are discussed.


ME/CFS is a multisystemic metabolic-inflammatory disorder.


The aberrations in IO&NS pathways

may increase the risk for cardiovascular disorders.



PMID: 20038921





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