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vervangen door SEID

is géén goede oplossing








Omdat het voor een aantal wetenschappers en politici kennelijk nog steeds niet duidelijk is,

heb ik een aantal relevante feiten m.b.t. ME, CVS en SEID in een artikel samengevat, zoals:




[T]he position that

ME and CFS are distinct, partially overlapping conditions,

is not a matter of opinion, but a matter of definition.




Zelfs als je dat zou willen,

kun je twee, elkaar deels overlappende verzamelingen niet door een derde verzameling vervangen...


Omdat SEID niet de oplossing is en zeggen hoe het niet moet makkelijk is,

wordt in het artikel ook een oplossing voor "de diagnostische impasse" aangedragen.






Replacing Myalgic Encephalomyelitis and chronic fatigue syndrome

with Systemic Exercise Intolerance Disease is not the way forward.

Diagnostics 2016, 6(1), 10. doi:10.3390/diagnostics6010010.

Twisk, FNM.




Myalgic encephalomyelitis (ME), described in the medical literature since 1938,

is characterized by

distinctive muscular symptoms, neurological symptoms, and signs of circulatory impairment.


The only mandatory feature of chronic fatigue syndrome (CFS),

introduced in 1988 and redefined in 1994, is chronic fatigue,

which should be accompanied by at least four or more out of eight "additional" symptoms.


The use of the abstract, polythetic criteria of CFS,

which define a heterogeneous patient population, and self-report

has hampered both scientific progress and accurate diagnosis.


To resolve the "diagnostic impasse"

the Institute of Medicine proposes that

a new clinical entity, systemic exercise intolerance disease (SEID),

should replace the clinical entities ME and CFS.


However, adopting SEID and its defining symptoms,

does not resolve methodological and diagnostic issues.


Firstly, a new diagnostic entity

cannot replace two distinct, partially overlapping, clinical entities such as ME and CFS.


Secondly, due to the nature of the diagnostic criteria,

the employment of self-report, and

the lack of criteria to exclude patients with other conditions,

the SEID criteria seem to select an even more heterogeneous patient population,

causing additional diagnostic confusion.


This article discusses methodological and diagnostic issues related to SEID and

proposes a methodological solution for the current "diagnostic impasse".





Myalgic encephalomyelitis; chronic fatigue syndrome;

systemic exercise intolerance disease; diagnosis; assessment