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Consensus Criteria

voor ME -


voor medici.







Vandaag verscheen de primer van de Internationale Consensus-criteria (ICC) voor ME.


De primer geeft nadere uitleg over de ICC aan medici (o.m. in de vorm van testen).




Voor de primer klik op onderstaande afbeelding:





Voor een grote versie van de samenvatting van de criteria, klik op onderstaande afbeelding:





International Consensus Criteria (ICC)





The label 'chronic fatigue syndrome' (CFS), coined in the 1980s,

has persisted due to lack of knowledge of its etiologic agents and pathophysiology.


Misperceptions have arisen

because the name 'CFS' and its hybrids ME/CFS, CFS/ME and CFS/CF

have been used for widely diverse conditions.


Patient sets can include those who are seriously ill with ME,

many bedridden and unable to care for themselves,

to those who have general fatigue or, under the Reeves criteria,

patients are not required to have any physical symptoms.


There is a poignant need to untangle the web of confusion

caused by mixing diverse and often overly inclusive patient populations

in one heterogeneous, multi-rubric pot called 'chronic fatigue syndrome'.


We believe this is the foremost cause of diluted and inconsistent research findings,

which hinders progress, fosters scepticism, and wastes limited research monies.





The rationale for the development of the ICC

was to utilize current research knowledge

to identify objective, measurable and reproducible abnormalities

that directly reflect the interactive, regulatory components of

the underlying pathophysiology of ME.


Specifically, the ICC select patients

who exhibit explicit multi-systemic neuropathology,

and have a pathological low threshold of physical and mental fatigability

in response to exertion.


Cardiopulmonary exercise test-retest studies

have confirmed many post-exertional abnormalities.


Criterial symptoms are compulsory and

identify patients who have greater physical, cognitive and functional impairments.


The ICC advance the successful strategy of the Canadian Consensus Criteria (CCC)

of grouping coordinated patterns of symptom clusters that identify areas of pathology.



The criteria are designed for both clinical and research settings.


1. Name:


Myalgic encephalomyelitis, a name that originated in the 1950s,

is the most accurate and appropriate name

because it reflects the underlying multi-system pathophysiology of the disease.


Our panel strongly recommends that

only the name 'myalgic encephalomyelitis' be used

to identify patients meeting the ICC

because a distinctive disease entity should have one name.


Patients diagnosed using

broader or other criteria for CFS or its hybrids (Oxford, Reeves, London, Fukuda, CCC, etc.)

should be reassessed with the ICC.


Those who fulfill the criteria have ME;

those who do not would remain in the more encompassing CFS classification.



2. Remove patients who satisfy the ICC from the broader category of CFS.


The purpose of diagnosis is to provide clarity.


The criterial symptoms,

such as the distinctive abnormal responses to exertion

can differentiate ME patients

from those who are depressed or have other fatiguing conditions.


Not only is it common sense to

extricate ME patients

from the assortment of conditions assembled under the CFS umbrella,

it is compliant with the WHO classification rule

that a disease cannot be classified under more than one rubric.


The panel is not dismissing the broad components of fatiguing illnesses,

but rather the ICC are a refinement of patient stratification.


As other identifiable patient sets are identified and supported by research,

they would then be removed from the broad CFS/CF category.



3. Research on ME:


The logical way to advance science is

to select a relatively homogeneous patient set

that can be studied to identify

biopathological mechanisms, biomarkers and disease process

specific to that patient set,

as well as comparing it to other patient sets.


It is counterproductive to use inconsistent and overly inclusive criteria

to glean insight into the pathophysiology of ME

if up to 90% of the research patient sets may not meet its criteria (Jason 2009).


Research on other fatiguing illnesses, such as cancer and multiple sclerosis (MS),

is done on patients who have those diseases.


There is a current, urgent need for

ME research using patients who actually have ME.



4. Research confirmation:


When research is applied to patients satisfying the ICC,

previous findings based on broader criteria will be confirmed or refuted.


Validation of ME being a differential diagnosis,

as is multiple sclerosis (MS), or a subgroup of chronic fatigue syndrome,

will then be verified.



5. Focus on treatment efficacy:


With enhanced understanding of

biopathological mechanisms, biomarkers and other components of pathophysiology

specific to ME,

more focus and research emphasis

can target expanding and augmenting treatment efficacy.