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met ME/CVS ná EBV

hebben een

objektief lagere







Een cohort-studie van Katz en kollega's onder adolescenten bevestigt dat

  • ca. 1 op de 8 mensen een half jaar na een "onschuldige" EBV-infektie aan de
  • diagnose "CVS" voldoet (klik hier voor een studie die tot eenzelfde konklusie kwam),

  • de zuurstofopname bij CVS-patiënten beduidend lager ligt (ca. 11%) én
  • die lage inspanningskapaciteit hoogstwaarschijnlijk niet het gevolg is van deconditionering.



Citaten uit het studierapport:





There have been 11 previous reports of exercise testing in adults with CFS that included comparison (control) groups. These studies differed in terms of the control groups examined (eg, normal vs sedentary), whether the sickest patients with CFS were excluded, whether the patients were encouraged to exercise to maximum capacity, and whether only females or both sexes were studied. Predictably, results varied as well, but most showed decreased exercise capacity and fitness levels in subjects with CFS, and inconsistent data regarding heart rate responses to exercise. 13-23 A single, uncontrolled pediatric study demonstrated that maximal exercise capacity was reduced in 5% to 30% of subjects with CFS. 24


Because there were no previous controlled pediatric trials, we undertook to prospectively examine exercise testing in our cohort of adolescents with CFS and recovered control subjects. Neither absolute nor percent predicted work capacity was statistically significantly different between recovered control subjects and patients with CFS. However, oxygen consumption, work slope, and peak oxygen pulse were significantly higher in recovered control subjects than in patients who met the criteria for CFS 6 months after IM, indicating a lower degree of fitness in CFS cases 6 months after IM versus recovered control subjects. The 11% difference in peak oxygen consumption between adolescents with CFS and recovered control subjects is likely clinically meaningful, because 10% to 25% increases in VO2 max are seen after aerobic training in normal individuals. 25


Because there were no abnormalities related to the efficiency of breathing, baseline lung function, or peak work capacity, we did see a greater rise in salivary cortisol in response to exercise in subjects with CFS, the lower degree of fitness we saw in our CFS cohort may be related to subtle regulatory abnormalities of cardiac function. We do not believe that there was a difference in conditioning between the 2 groups because both baseline resting heart rate and peak hear rate were similar between the 2 groups.




Exercise tolerance testing in a prospective cohort of adolescents with chronic fatigue syndrome and recovered controls following infectious mononucleosis

J Pediatr 2010; 10.1016/j.jpeds.2010.03.025.

Ben Z. Katz, MD, Steven Boas, MD, Yukiko Shiraishi, PhD, Cynthia J. Mears, DO, and Renee Taylor, PhD





Six months after acute infectious mononucleosis (IM),

13% of adolescents meet criteria for chronic fatigue syndrome (CFS).


We measured

exercise tolerance in adolescents with CFS and control subjects 6 months after IM.



Study design


Twenty-one adolescents with CFS 6 months after IM and

21 recovered control subjects

performed a maximal incremental exercise tolerance test

with breath-by-breath gas analysis.


Values expressed are mean ± standard deviation.





The adolescents diagnosed with CFS and control subjects

did not differ in age, weight, body mass index, or peak work capacity.


Lower oxygen consumption peak percent of predicted was seen

in adolescents with CFS compared with control subjects

(CFS 99.3 ± 16.6 vs control subject 110.7 ± 19.9, P = .05).


Peak oxygen pulse also was lower in adolescents with CFS

compared with recovered control subjects

(CFS 12.4 ± 2.9 vs control subjects 14.9 ± 4.3, P = .03).





Adolescents with CFS 6 months after IM

have a lower degree of fitness and efficiency of exercise than recovered adolescents.


Whether these abnormal exercise findings are a cause or effect of CFS is unknown.


IM can lead to both fatigue and measurable changes in exercise testing

in a subset of adolescents.