een op maat gesneden,

kombinatie van supplementen

lijkt veelbelovend.









Op basis van een systematische beoordeling van bestaande studies, stellen Jason et al. dat,

gezien het gerapporteerde succes van individuele supplementen

ťn het feit dat elke ME/CVS-patiŽnt anders is en anders behandeld moet worden,

er in de toekomst meer onderzoek gedaan zou moeten worden naar

de (positieve) effecten van een combinatie van supplementen "op maat".


Ik hoop wel dat toekomstig onderzoek op basis van harde maatstaven uitgevoerd wordt.




Alternative medical interventions used in the treatment and management of myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia.

J Altern Complement Med. 2010 Mar;16(3):235-49.

Porter NS, Jason LA, Boulton A, Bothne N, Coleman B.


Center for Community Research,

DePaul University,

Chicago, IL.






There have been

several systematic reviews

attempting to evaluate

the efficacy of

possible treatments for

myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and

fibromyalgia (FM).



information regarding

the efficacy of

complementary and

alternative medicine (CAM)

has not been comprehensively or systematically covered

in these reviews,


its frequent use

in the patient community.





The purpose of this study was

to systematically review and evaluate the current literature

related to alternative and complementary treatments for ME/CFS and FM.


It should be stressed that

the treatments evaluated

in this review

do not reflect

the clinical approach used by most practitioners

to treat these illnesses,

which include

a mix of

natural and unconventionally used medications and natural hormones

tailored to each individual case.



nearly all clinical research has focused on

the utility of single CAM interventions, and

thus is the primary focus of this review.





Several databases (e.g., PubMed, MEDLINE,((R)) PsychInfo)

were systematically searched

for randomized and nonrandomized controlled trials of

alternative treatments and non-pharmacological supplements.


Included studies were checked for references and

several experts were contacted for referred articles.


Two leading subspecialty journals were also searched by hand.


Data were then extracted from included studies and

quality assessments were conducted using the Jadad scale.





Upon completion of the literature search and the exclusion of studies

not meeting criterion,

a total of 70 controlled clinical trials were included in the review.


Sixty (60) of the 70 studies

found at least one positive effect of the intervention (86%), and

52 studies also found improvement in an illness-specific symptom (74%).


The methodological quality of reporting was generally poor.





Several types of alternative medicine

have some potential for future clinical research.



due to methodological inconsistencies across studies and the small body of evidence,

no firm conclusions can be made at this time.


Regarding alternative treatments,

acupuncture and several types of meditative practice

show the most promise for future scientific investigation.



magnesium, l-carnitine, and S-adenosylmethionine

are non-pharmacological supplements

with the most potential for further research.


Individualized treatment plans

that involve several pharmacological agents and natural remedies

appear promising as well.




PMID: 20192908 [PubMed - in process]