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signifikante hersenafwijkingen



specifieke klachten verklaren.









Puri en kollega's hebben m.b.v. de voxel-based morphometry-analysetechniek

vastgesteld dat het volume van de grijze en witte hersenstof van 26 ME/CVS-patiŽnten

op specifieke plekken signifikant minder is dan die van gezonde personen.


Afname van en afwijkingen in de grijze en witte hersenstof van ME/CVS-patienten

zijn eerder ook door anderen aangetoond (bijvoorbeeld: klik hier en hier).


Nu maar hopen dat de grijze en witte hersenstof zich iets aantrektken van CGT....




Regional grey and white matter volumetric changes in myalgic encephalomyelitis (chronic fatigue syndrome): a voxel-based morphometry 3-T MRI study.

British Journal of Radiology. November 29, 2011. doi:10.1259/bjr/93889091.

B K Puri, P M Jakeman, M Agour, K D R Gunatilake, K A C Fernando, A I Gurusinghe, I H Treasaden, A D Waldman, P Gishen.





It is not established

whether myalgic encephalomyelitis/chronic fatigue syndrome (CFS)

is associated with structural brain changes.


The aim of this study was to investigate this

by conducting the largest voxel-based morphometry study to date in CFS.





High-resolution structural 3-T cerebral MRI scanning

was carried out

in 26 CFS patients and 26 age- and gender-matched healthy volunteers.


Voxel-wise generalised linear modelling

was applied to the processed MR data

using permutation-based non-parametric testing,

forming clusters at t > 2.3 and

testing clusters for significance at p < 0.05,

corrected for multiple comparisons across space.





Significant voxels (p < 0.05, corrected for multiple comparisons)

depicting reduced grey matter volume in the CFS group were noted

in the occipital lobes

(right and left occipital poles; left lateral occipital cortex,

superior division; and left supracalcrine cortex),

the right angular gyrus and the posterior division of the left parahippocampal gyrus.


Significant voxels (p < 0.05, corrected for multiple comparisons)

depicting reduced white matter volume in the CFS group

were also noted in the left occipital lobe.





These data support the hypothesis that

significant neuroanatomical changes occur in CFS, and

are consistent with the complaint of impaired memory

that is common in this illness;

they also suggest that

subtle abnormalities in visual processing,

and discrepancies between intended actions and consequent movements,

may occur in CFS.