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Diagnosecriteria SEID

zijn nog ruimer dan

de diagnosecriteria

voor CVS.








Mijn veronderstelling dat grote groepen mensen met andere medische aandoeningen en

psychische problemen, zoals depressie, k aan de de diagnosecriteria voor SEID voldoen,

wordt bevestigd door twee studies van de onderzoeksgroep van prof. Lenny Jason.


De SEID-criteria nauwelijks strenger zijn dan de CVS/Fukuda-criteria (studie 1) en

een substantieel deel van de mensen met chronische vermoeidheid (44%-47%), depressie

(24-27%), MS (33%), lupus (47%) voldoet ook aan de diagnosecriteria voor SEID (studie 2).


Samengevat, introductie van SEID zal onderzoek van ME alleen nog maar verder doen compliceren.





Chronic fatigue syndrome versus systemic exertion intolerance disease.

Fatigue: Biomedicine, Health & Behavior. 2015 Jun 15.

doi: 10.1080/21641846.2015.1051291.

Jason LA, Sunnquist M, Brown A, Newton JL, Strand EB, Vernon SD.






The Institute of Medicine has recommended

a change in the name and criteria for chronic fatigue syndrome (CFS),

renaming the illness systemic exertion intolerance disease (SEID).


The new SEID case definition

requires substantial reductions or impairments in the ability to engage in pre-illness activities,

unrefreshing sleep, post-exertional malaise, and

either cognitive impairment or orthostatic intolerance.





In the current study,

samples were generated through several different methods and

were used to compare this new case definition to previous case definitions for CFS,

the InternationalConsensus Criteria for myalgic encephalomyelitis (ME-ICC),

the Canadian myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) definition,

as well as a case definition developed through empirical methods.





We used a cross-sectional design with samples from

tertiary care settings, a BioBank sample, and other forums.


Seven hundred and ninety-six patients from the USA, Great Britain, and Norway

completed the DePaul Symptom Questionnaire.



Findings indicated that

the SEID criteria identified 88% of participants in the samples analyzed,

which is comparable to the 92% that met the Fukuda criteria.


The SEID case definition was compared to a four-item empiric criteria, and

findings indicated that the four-item empiric criteria

identified a smaller, more functionally limited and symptomatic group of patients.





The recently developed SEID criteria appears to identify

a group comparable in size to the Fukuda et al. criteria,

but a larger group of patients than the Canadian ME/CFS and ME criteria, and

selects more patients who have less impairment and fewer symptoms

than a four-item empiric criteria.





Systemic exertion intolerance disease, Myalgic Encephalomyelitis,

chronic fatigue syndrome, case definitions





Unintended consequences of not specifying exclusionary illnesses

for systemic exertion intolerance disease.

Diagnostics 2015, 5(2), 272-286; doi:10.3390/diagnostics5020272.

Jason LA, Sunnquist M, Kot B, Brown A.





The Institute of Medicine recently proposed a new case definition for chronic fatigue syndrome (CFS),

as well as a new name, Systemic Exertion Intolerance Disease (SEID).


Contrary to the Fukuda et al.s CFS case definition,

there are few exclusionary illnesses specified for this new SEID case definition.


The current study explored this decision regarding exclusionary illnesses

using the SEID criteria with four distinct data sets

involving patients who had been identified as having CFS,

as well as healthy controls, community controls, and other illness groups.


The findings indicate that

many individuals from major depressive disorder illness groups

as well as other medical illnesses were categorized as having SEID.


The past CFS Fukuda et al. prevalence rate in a community based sample of 0.42

increased by 2.8 times with the new SEID criteria.


The consequences for this broadening of the case definition are discussed.




Myalgic Encephalomyelitis; chronic fatigue syndrome; systemic exertion intolerance disease; case definitions