Follow FrankTwisk on Twitter  







gaat gepaard met



én immuundysfunctie






Volgens een recente studie van Marshall-Grasdinik en collega's van de Gold Coast Univeristy

gaat ME/CVS gepaard met een scala aan "medisch onverklaarbare" immunologische afwijkingen:

En nu maar hopen dat al die verschillende afweercellen luisteren naar gedragstherapie...







Analysis of the relationship between immune dysfunction and symptom severity

in patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)

J Clin Cell Immunol 2014, 5: 190. doi: 10.4172/2155-9899.1000190

Hardcastle SL, Brenu EW, Johnston S, Nguyen T, Huth T, Kaur M,

Ramos S, Salajegheh A, Staines D, Marshall-Gradisnik S.








Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is a disabling illness,

characterised by persistent, debilitating fatigue and a multitude of symptoms.


Immunological alterations are prominent in CFS/ME cases,

however little is known about the relationship

between CFS/ME severity and the extent of immunological dysfunction.


The purpose of this study was to assess

innate and adaptive immune cell phenotypes and function of

two groups of CFS/ME patients, bedridden (severe) and mobile (moderate).





CFS/ME participants were defined

using the Centres for Disease Prevention and Control (1994 CDC) Criteria for CFS/ME.


Participants were grouped into

healthy controls (n=22, age=40.14 ± 2.38),

moderate/mobile (n=23; age=42.52 ± 2.63) and

severe/bedridden (n=18; age=39.56 ± 1.51) CFS/ME patients.


Flow cytometric protocols were used to examine

neutrophil, monocyte, dendritic cells (DCs), iNKT, Treg,

B, γδ and CD8+ T cell phenotypes,

NK cytotoxic activity and receptors.





The present data found that

CFS/ME patients demonstrated

significant decreases in

NK cytotoxic activity, transitional and regulatory B cells,

γδ1 T cells, KIR2DL1/DS1, CD94+ and KIR2DL2/L3.


Significant increases in

CD56-CD16+ NKs, CD56dimCD16- and CD56brightCD16-/dim NKs,

DCs, iNKT phenotypes, memory and naive B cells

were also shown in CFS/ME participants.


Severe CFS/ME patients demonstrated

increased CD14-CD16+ DCs, memory and naïve B cells,

total iNKT, iNKT cell and NK phenotypes

compared to moderate CFS/ME patients.





This study is the first to determine alterations in

NK, iNKT, B, DC and T cell phenotypes

in both moderate and severe CFS/ME patients.


Immunological alterations are present in innate and adaptive immune cells and

sometimes, immune deregulation appears worse in CFS/ME patients with more severe symptoms.


It may be appropriate for CFS/ME patient severity subgroups

to be distinguished in both clinical and research settings

to extricate further immunological pathologies

that may not have been previously reported.





Chronic Fatigue Syndrome, Severity, γδ T cells, Immune,

Natural Killer Cell, iNKT, Cytotoxic Activity, Adaptive