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Up-regulation of TGF-β1 mRNA expression in peripheral blood mononuclear cells of patients with chronic fatigue syndrome.

J Formos Med Assoc. 2011 Nov;110(11):701-4. doi:10.1016/j.jfma.2011.09.006.

Zhang HY, Liu ZD, Hu CJ, Wang DX, Zhang YB, Li YZ.





It has been shown that the abnormality

in immune cells in chronic fatigue syndrome (CFS) patients

is closely associated with the participation of TGF-β.


In order to study the relationship between TGF-β1 and CFS,

we investigated the mRNA levels of TGF-β1

in peripheral blood mononuclear cells (PBMCs) in patients with CFS.





Fluorescent quantitative real time reverse-transcription

polymerase chain reaction (FQ-RT-PCR) was performed to test

TGF-β1 mRNA expression in PBMCs

in 63 cases of CFS, 50 cases of disease controls, and 50 cases of healthy controls.





The mean value of TGF-β1 mRNA expression in CFS patients was ΔΔCt=1.170.58,

which was significantly higher than

the disease controls (ΔΔCt=0.071.08, df=111, p < 0.01) and

the healthy controls (ΔΔCt=0.001.63, df=111, p < 0.01).


No significant difference was detected

between disease and healthy controls (p > 0.05).





The expression of TGF-β1 in PBMCs

is significantly elevated in patients with CFS.


It might be correlated to the pathogenesis of the disease.




PMID: 22118314